Figure 1.

Example of anti-LGI-1 (case 2): (a) Neurostat: the first row shows surface projections of brain metabolism (visual assessment); the second row shows significant decreases in brain metabolism (red to green); and the third row shows significant increases (red to green) in brain metabolism as compared to an adjusted normal database. (b) syngo.via Database Comparison, and (c) Statistical Parametric Mapping (SPM 12). Statistical surface projections using Neurostat (a) and syngo.via Database Comparison (b) assessment distinguished better than SPM the frontal, lateral temporal and parietal hypometabolism, whereas hypermetabolic areas involving basal ganglia, cerebellar vermis and the medial aspect of the right temporal lobe were seen by the three methods. Color bars represent significant increases or decreases in brain metabolism compared to a normal database stratified by age. In the displayed Neurostat and SPM results, all the colored voxels represent statistical significance when compared to normal controls (Neurostat: increases and decreases in red to green; SPM: increases in, red to yellow, decreases in blue) whereas in the syngo.via Database Comparison, the significant voxels can be identified according to the SD color bar, 2 SD being the threshold of statistical significance (i.e., areas with green voxels are not significant). See also Table 2.