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. 2020 Jul 8;77(11):1–11. doi: 10.1001/jamapsychiatry.2020.1619

Table 3. Spearman Partial Correlation Coefficients for Association Between Duration of Untreated Psychosis and Cognitive Outcomesa .

Test Untreated patients with test results with confirmed validity All untreated patients (N = 197)b
No. of tests Spearman ρ P value Spearman ρ P value
MMSE, total 189 −0.14 .05 −0.10 .16
Overall MCCB
Test results with indeterminate validity, No. NA NA NA 0.18 .01
Cognitive domains with indeterminate validity, No. NA NA NA 0.19 .009
Specific MCCB testsc
TMT-A, s 143 0.10 .43 0.17 .03
BACS Symbol Coding, No. 136 −0.35 <.001 −0.32 <.001
HVLT-R, total 157 −0.08 .44 −0.16 .03
WMS-III Spatial Span, total 156 −0.07 .47 −0.10 .15
NAB Mazes, index 160 −0.24 .01 −0.24 .003
BVMT-R, total 158 −0.20 .04 −0.24 .003
CF Animal Naming, No. 152 −0.09 .43 −0.12 .11
CPT-IP, meand 112 −0.19 .10 −0.17 .03
RMET-CV-R, No.c 96 −0.004 .97 −0.16 .03

Abbreviations: BACS Symbol Coding, Brief Assessment of Cognition in Schizophrenia, Symbol Coding subtest; BVMT-R, Brief Visuospatial Memory Test–Revised; CF Animal Naming, Category Fluency, Animal Naming test; CPT-IP, Continuous Performance Test–Identical Pairs version; HVLT-R, Hopkin’s Verbal Learning Test–Revised; MCCB, Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognition Battery; MMSE, Mini-Mental Status Examination; NA, not applicable; NAB Mazes, Neuropsychological Assessment Battery, Mazes subtest; RMET-CV-R, Reading the Mind in the Eyes Test, revised Chinese version; TMT-A, Trail Making Test, Part A; WMS-III Spatial Span, Wechsler Memory Scale, third edition, Spatial Span subtest.

a

Includes test results with confirmed validity and all test results of untreated patients on the MMSE and 9 cognitive tests (8 tests from the MCCB plus the RMET-CV-R).

b

The worst possible scores were assigned to tests with indeterminate validity. For the TMT-A, the worst possible score was 300 seconds. For all specific MCCB tests and the RMET-CV-R, the worst possible score was 0.

c

P values were adjusted for false discovery rates.

d

Calculated using d′ reaction time.