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. 2020 May 31;18(6):288. doi: 10.3390/md18060288

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effects of OPs on UVB-induced epidermal cyclooxygenase-2 (COX-2) and dermic matrix metalloproteinase-1 (MMP-1) expressions in dorsal skin of mice. (A) Representative photographs of epidermal COX-2 distribution by IHC staining (400×); Scale bar = 50 μm. (B) Representative photographs of epidermal MMP-1 distribution by IHC staining (400×); Scale bar = 50 μm. (C) Relative COX-2 positive expression in epidermal layer was assessed by comparing the number of COX-2 positive cells in different groups vs. in the control group from 10 equal sections of immune-stained dorsal skin per animal (n = 4). (D) Relative MMP-1 positive expression in dermis layer was assessed by comparing the number of COX-2 positive cells in different groups vs. in the control group from 10 equal sections of immune-stained dorsal skin per animal (n = 4). ** p < 0.01, compared with the CT group; ^# p < 0.05 and ^## p < 0.01 compared with the UVB group.