SCFAs	Short-chain fatty acids
FFAR2	Free fatty acid receptor 2
FFAR3	Free fatty acid receptor 3
GPCRs	G-coupled protein receptors
T1D	Type 1 diabetes
T2D	Type 2 diabetes
IBD	Inflammatory bowel disease
TM	Transmembrane
PBMCs	Peripheral blood mononuclear cells
PMNs	Polymorphonuclear cells
DCs	Dendritic cells
WAT	White adipose tissue
BAT	Brown adipose tissue
bMEC	Bovine mammary epithelial cell line
SNS	Sympathetic nervous system
CNS	Central nervous system
CRC	Colorectal cancer
SCG	Superior cervical ganglia
CSMG	Celiac sympathetic-mesenteric ganglia
GI	Gastrointestinal
AAs	Amino acids
Tyr	Tyrosine
Ile	Isoleucine
Arg	Arginine
Glu	Glutamate
EL	Extracellular loop
SCAs	Small carboxylic acids
Trp	Tryptophan
Gln	Glutamine
His	Histidine
Thr	Threonine
Phe	Phenylalanine
Leu	Leucine
SAR	Structure activity relationship
Å	Angstrom
SASA	Solvent accessible surface area
H	Hydrogen
PYY	Peptide YY
Cmp1	Compound 1
CFMB/Phenylacetamide 1	[(S)-2-(4-chlorophenyl)-3,3-dimethyl- N-(5-phenylthiazol-2-yl)butamide
AMG-7703	(2S)-2-(4-chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanamide
Val	Valine
4-CMTB	2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide
2CTAP	4-((4-(2-chlorophenyl)thiazole-2-yl)amino)-4oxo-3-phenylbutanoic acid
BTI-A-404	[4-[4-(dimethylamino)phenyl]-N-(3,5-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide]
BTI-A-292	[4-[4-(dimethylamino) phenyl]-N-(4,5-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide]
CATPB	(S)-3-(2-(3-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid
GLPG0974	4-[[(2R)-1-(1-benzothiophene-3-carbonyl)-2-methylazetidine-2-carbonyl]-[(3-chlorophenyl)methyl]amino]butanoic acid
Compound 1	3-benzyl-4-(cyclopropyl-(4-(2,5-dichlorophenyl)thiazol-2-yl)amino)-4-oxobutanoic acid
Phenylacetamide 2/Compound 44	(S)-2-(4-chlorophenyl)-N-(5-fluorothiazol-2-yl)-3-methylbutanamide
Phenylacetamide 58	(S)-2-(4-chlorophenyl)-3,3-dimethyl-N-(5-phenylthiazol-2-yl)butanamide
1-MCPC	1-methylcyclopropane carboxylate; AR420626: N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxamide
CF3-MQC	N-(2-methylphenyl)-4-[5-(2-trifluoromethoxy-phenyl)-furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
MQC	N-[2-methylphenyl]-[4-furan-3-yl]-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
DSS	Dextran sodium sulphate
LPS	Lipopolysaccharide
MAPK	Mitogen-activated protein kinase
Ig	Immunoglobulin
CRAMP	Cathelicidin related antimicrobial peptide
NFκB	Nuclear factor kappa-light-chain-enhancer of activated B cells
AMPK-α	5’ adenosine monophosphate-activated protein kinase
PI3K	Phosphatidylinositol 3-kinase
Akt	Protein Kinase B
ERK	Extracellular signal-regulated kinases
INFγ	Interferon gamma
PTX	Pertussis toxin
JNK	c-Jun N-terminal kinase
iNOS	Induced nitric oxide synthase
HUVEC	Human umbilical vein endothelial cells
HDACi	Histone deacetylases inhibitor
Treg	Regulatory T-cells
WT	Wild type
mTOR	The mammalian target of rapamycin
eNOS	Exhaled nitric oxide
TNF-α	Tumor Necrosis Factor alpha
GIT	Gastrointestinal tract
GLP-1	Glucagon-like peptide 1
POMC	Pro-opiomelanocortin
NPY	Neuropeptide Y
AgRP	Agouti-related peptide
qRTPCR	Quantitative reverse transcription polymerase chain reaction
5-HT	Hydroxytryptamine
5-HCO3-	Bicarbonate
cAMP	Cyclic adenosine monophosphate
FACS	Fluorescence-activated cell sorting
mRFP	Monomeric red fluorescent protein
GIP	Gastric inhibitory polypeptide
RYGB	Roux-en-Y gastric bypass
M-cells	Myeloid cells
IECs	Intestinal epithelial cells
5-HT	5-Hydroxytryptamine
IL	Interleukin
Tjp1	Tight junction protein 1
Ocln	Occludin
Cldn	Claudin
Muc	Mucin
AMPK	AMP-activated protein kinase
HIF	Hypoxia-inducible factor
DSS	Dextran sodium sulphate
TNBS	Trinitrobenzoic sulphonic acid
PNS	Peripheral nervous system
BBB	Blood brain barrier
TH	Tyrosine hydroxylase
PLC	Phospholipase C
nAChR	Nicotinic acetylcholine receptor
Ca	Calcium
IP	Intraperitoneal
DIO	Diet induced obese
HFD	High fat diet
siRNA	Small interfering ribonucleic acid
PPARγ	Peroxisome proliferator-activated receptor gamma
hMADS	Human multipotent adipose tissue-derived stem
NC	Normal chow
OGTT	Oral glucose tolerance test
IM-BAT	Immortalized brown adipocyte cell line
GSIS	Glucose-stimulated insulin secretion
DSS	Dextran sodium sulphate
DAI	Daily activity index