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Mechanisms of antibody combinations. (A) Antibody combinations targeting two ICI, either as single MAbs or BsAbs. (B) Two MAbs targeting an ICI and a tumor antigen, these can also be combined in a BsAb format. (C) Combination of a MAb targeting an ICI with a TE BsAb and (D) an ICI antibody can be combined with MAbs blocking different pathways involved in tumor growth and metastasis, such as antibodies blocking angiogenic or growth factors, or complement factors and their receptors.
