Table 1.
Fc-Glycans | Potential Effects | References |
---|---|---|
Fucose |
Absence of core fucose enhances:
|
[48,51,52,53,54] |
Galactose | Enhances antibody binding to C1q and CDC | [44,45] |
Sialic acid |
|
[36,39] [35,36] [18,19,20] [3,25] |
High Mannose |
|
[17,25,29] [55] [29,55] |
Bisecting GlcNAc | Increases FcγRIIIa binding and ADCC activity | [44,47,48,49] |