Table 1.

Pharmacological Classes of Antidepressants.

Pharmacological Class	Neuroscience Based Class	Primary Target(s) 1	Examples
SSRI	5HT reuptake inhibitor	SERT	Citalopram, Sertraline
SSRI-‘plus’	5HT multimodal modulator	SERT and 5HT receptors	Vortioxetine
SNRI	5HT/NE reuptake inhibitor	SERT and NET	Venlafaxine, Duloxetine
TCA	NE reuptake inhibitor	SERT and NET	Imipramine, Desimpramine
MAOI	5HT, NE, DA multimodal modulator	MAO enzyme	Tranylcypromine
Atypical	DA/NE modulator	DAT and NET	Bupropion
Glutamate	Glutamate antagonist	NMDA	Esketamine, Ketamine

¹ Information taken from Neuroscience Based Nomenclature [9]. SSRI = selective serotonin reuptake inhibitor; 5HT = 5 hydroxytryptophan; SNRI = serotonin-norepinephrine reuptake inhibitor; NE = norepinephrine; TCA = tricyclic antidepressant; MAOI = monoamine oxidase inhibitor; DA = dopamine.