Table 2.

Pharmacological Classes of Augmentation Agents for Depression.

Pharmacological Class	Neuroscience Based Class	Primary Target(s) 1	Examples
Mood stabilizers	Lithium enzyme modulator	Phosphatidyl-inositol pathway 2	Lithium
SGA	DA/5HT antagonist, other	D2, 5HT1A, 5HT2A	Aripiprazole, Quetiapine
Thyroid	N/A	Thyroid hormone receptor	Liothyronine, Levothyroxine
Anticonvulsants	Glutamate channel blocker, other	Voltage-gated sodium channels, other	Lamotrigine, Valproate
Other	5HT partial agonist	5HT1A	Buspirone

¹ Information taken from Neuroscience Based Nomenclature [9]. ² Information taken from Brown et al. [10]; SGA = second generation antipsychotic.