Table 4.
List of Included Second Generation Antipsychotic Studies.
| Trial | Treatment Comparators |
|---|---|
| Marcus et al., 2008 [27] | Aripiprazole plus antidepressant; placebo plus antidepressant |
| Berman et al., 2009 [29] | Aripiprazole plus antidepressant; placebo plus antidepressant |
| Yoshimura et al., 2012 [30] | Aripiprazole plus Paroxetine; Aripiprazole plus Sertraline |
| Fava et al., 2012 [31] | Aripiprazole plus antidepressant; placebo plus antidepressant |
| Yoshimura et al., 2014 [52] | Lithium plus Paroxetine; Olanzapine plus Paroxetine; Aripiprazole plus Paroxetine |
| Han et al., 2015 [28] | Aripiprazole plus antidepressant; switching antidepressants |
| Mohammed et al., 2017 [15] | Aripiprazole plus antidepressant; Bupropion plus antidepressant; switching to Bupropion |
| Dorée et al., 2007 [53] | Quetiapine plus antidepressant; Lithium plus antidepressant |
| Bauer et al., 2009 [40] | Quetiapine XR plus antidepressant; placebo plus antidepressant |
| Cutler et al., 2009 [38] | Quetiapine XR; Duloxetine |
| El-Khalili et al., 2010 [39] | Quetiapine XR plus antidepressant; placebo plus antidepressant |
| Bauer et al., 2013 [54] | Quetiapine XR plus antidepressant; Quetiapine XR; lithium plus antidepressant |
| Hobart et al., 2018 [41] | Quetiapine plus antidepressant; Brexpiprazole plus antidepressant; placebo plus antidepressant |
| Mahmoud et al., 2007 [47] | Risperidone plus antidepressant; placebo plus antidepressant |
| Reeves et al., 2008 [46] | Risperidone plus antidepressant; placebo plus antidepressant |
| Keitner et al., 2009 [48] | Risperidone plus antidepressant; placebo plus antidepressant |
| Fang et al., 2011 [49] | Valproate plus Paroxetine; Risperidone plus Paroxetine; Buspirone plus Paroxetine; Trazodone plus Paroxetine; Thyroid Hormone plus Paroxetine |
| Thase et al., 2015 [43] | Brexpiprazole plus antidepressant; placebo plus antidepressant |
| Thase et al., 2015 [44] | Brexpiprazole plus antidepressant; placebo plus antidepressant |
| Shelton et al., 2001 [33] | Olanzapine plus Fluoxetine; Olanzapine plus placebo; Fluoxetine plus placebo |
| Shelton et al., 2005 [35] | Olanzapine plus Fluoxetine; Olanzapine; Fluoxetine; Nortriptyline |
| Corya et al., 2006 [36] | Olanzapine plus Fluoxetine; Olanzapine; Fluoxetine; Venlafaxine |
| Thase et al., 2007 [34] | Olanzapine plus Fluoxetine; Fluoxetine; Olanzapine |
| Papakostas et al., 2012 [51] | Ziprasidone; placebo |
| Papakostas et al., 2015 [50] | Ziprasidone plus Escitalopram; placebo plus Escitalopram |
XR = extended release.