Figure 2.

(A–C) Antimicrobial activity of vancomycin-lipopeptide conjugates (different modification sites) for a clinical isolate of Enterococcus faecium (UL602570). The dotted line indicates the minimum inhibitory concentration (MIC) of the respective conjugate modified only with the peptide sequence. (D) Comparison of all three modification sites. The dotted line represents the enterococci resistance breakpoint. Data are shown as the median of a minimum of three independent experiments tested at least in duplicate. A tabular overview is shown in the supplementary information, Table S1.