Table 1.
Examples of frequently used beta blockers and antineoplastic agents.
| Pharmaceutical | Class | Chemical Formula | Structure | CAS |
|---|---|---|---|---|
| Atenolol | BB-B1 | C14H22N2O3 |
|
29122-68-7 |
| Celiprolol | BB-B1 | C20H33N3O4 |
|
56980-93-9 |
| Metoprolol | BB-B1 | C15H25NO3 |
|
51384-51-1 |
| Bisoprolol | BB-B1 | C18H31NO4 |
|
66722-44-9 |
| Nebivolol | BB-B1 | C22H25F2NO4 |
|
99200-09-6 |
| Propranolol | BB-NS | C16H21NO2 |
|
525-66-6 |
| Sotalol | BB-NS | C12H20N2O3S |
|
3930-20-9 |
| Carvedilol | BB-NS | C24H26N2O4 |
|
72956-09-3 |
| Labetalol | BB-NS | C19H24N2O3 |
|
36894-69-6 |
| Timolol | BB-NS | C13H24N4O3S |
|
26839-75-8 |
| Busulfan | AA-Alk | C6H14O6S2 |
|
55-98-1 |
| Carmustine | AA-Alk | C5H9Cl2N3O2 |
|
154-93-8 |
| Cyclophosphamide | AA-Alk | C7H15Cl2N2O2P |
|
50-18-0 |
| Estramustin | AA-Alk | C23H31Cl2NO3 |
|
2998-57-4 |
| Lomustine | AA-Alk | C9H16ClN3O2 |
|
13010-47-4 |
| Mesna | AA-Alk | C2H5NaO3S2 |
|
19767-45-4 |
| Carboplatin | AA-AlkRel | C6H12N2O4Pt |
|
41575-94-4 |
| Cisplatin | AA-AlkRel | Cl2H6N2Pt |
|
15663-27-1 |
| Disulfiram | AA-AlkRel | C10H20N2S4 or ((C2H5)2NCS)2S2 |
|
97-77-8 |
| Procarbazine | AA-AlkRel | C12H19N3O |
|
671-16-9 |
| Fluorouracil | AA-AntMet | C4H3FN2O2 |
|
51-21-8 |
| Methotrexate | AA-AntMet | C20H22N8O5 |
|
59-05-2 |
| Tegafur | AA-AntMet | C8H9FN2O3 |
|
17902-23-7 |
| Irinotecan | AA-Top-1Inh | C33H38N4O6 |
|
97682-44-5 |
| Topotecan | AA-Top-1Inh | C23H23N3O5 |
|
123948-87-8 |
| Etoposide | AA-Top-2Inh | C29H32O13 |
|
33419-42-0 |
| Teniposide | AA-Top-2Inh | C32H32O13S |
|
29767-20-2 |
| Bleomycin | AA-DNAIntAg | C55H84N17O21S3+ |
|
11056-06-7 |
| Daunorubicin | AA-DNAIntAg | C27H29NO10 |
|
20830-81-3 |
| Doxorubicin | AA-DNAIntAg | C27H29NO11 |
|
23214-92-8 |
| Epirubicin | AA-DNAIntAg | C27H29NO11 |
|
56420-45-2 |
| Idarubicin | AA-DNAIntAg | C26H27NO9 |
|
58957-92-9 |
| Docetaxel | AA-IntTub | C43H53NO14 |
|
114977-28-5 |
| Paclitaxel | AA-IntTub | C47H51NO14 |
|
33069-62-4 |
| Vinblastine | AA-IntTub | C46H58N4O9 |
|
865-21-4 |
| Vincristine | AA-IntTub | C46H56N4O10 |
|
57-22-7 |
| Imatinib | AA-TyrKinInh | C29H31N7O |
|
152459-95-5 |
| Lapatinib | AA-TyrKinInh | C29H26ClFN4O4S |
|
231277-92-2 |
| Amsacrine | AA-Other | C21H19N3O3S |
|
51264-14-3 |
| Hydroxyurea | AA-Other | CH4N2O2 |
|
127-07-1 |
| Pentostatin | AA-Other | C11H16N4O4 |
|
53910-25-1 |
BB—Beta Blocker; B1—Beta 1 selective; NS—Non-Selective; AA—Antineoplastic Agent; Alk—Alkylating, AlkRel—Alkylating Related; AntMet—Antimetabolite; Top-1Inh—Topoisomerase-1 inhibitor; Top-2Inh—Topoisomerase-2 inhibitor; DNAIntAg—DNA-intercalating agents; IntTub—Interfere with tubulin; TyrKinInh—Tyrosine-kinase inhibitors.