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. 2020 Jun 8;10(6):234. doi: 10.3390/metabo10060234

Figure 1.

Figure 1

(A) Heatmaps generated by the machine-learning algorithm Random Forests of the top 100 ions at 4 and 24 h after 8 Gy total body irradiation for wild-type (WT) mice and at 4 and 24 h after 10 Gy for p53−/− mice. More pronounced fold decreases of ions were observed at 4 h in WT compared to p53−/−. (B) Volcano plots generated from MetaboLyzer at 24 h post-irradiation for WT (8 and 10 Gy) or p53−/− (10 Gy) mice. Red inserts highlight the increased number of significant spectral features, showing higher perturbation in WT after a 10-Gy ionizing radiation (IR) dose compared to 8 Gy. Fewer significant ions were present in p53-deficient mice.