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Receiver operating characteristic analysis of wild-type (WT) mice and p53−/− mice. The highest specificity and sensitivity was obtained for carnitine and N1-acetylspermidine grouped at 4 h for the equitoxic dose (8 Gy) (area under the curve (AUC) = 0.91), with box and whisker plots illustrating higher concentration in WT vs. p53−/− mice urine post-irradiation. Classification performance was fair for the equidose (10 Gy) (AUC = 0.73).
