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. 2020 May 26;6(2):19. doi: 10.3390/ncrna6020019

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Knockdown of HOTAIR inhibits vasculogenic mimicry. After 48 h of incubation in hypoxia, breast cancer cells were placed on matrigel, and then imaged at the indicated times (0–9 h). (A) Vasculogenic mimicry images of MDA-MB-231 cells treated with DsiRNA HOTAIR inhibitor (right panel), scrambled (middle panel), and non-transfected control (left panel) conditions; (B,C) Graphical representation of the number of branch points and capillary tubes from panel A; (D) Vasculogenic mimicry images of Hs-578t cells treated with DsiRNA HOTAIR inhibitor (right panel), scrambled (middle panel), and non-transfected control (left panel) conditions; (E,F) Graphical representation of the number of branch points and capillary tubes from panel D. Experiments were performed three times by triplicate and data were expressed as mean ± S.D. **p < 0.05.