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Alp1 co-localizes with bronchial smooth muscle in asthma. (a) Representative Alp1 immunohistochemistry in lung biopsies from a cohort of healthy control subjects (FEV1 > 80% predicted) and patients with asthma (FEV1 < 80% predicted). Patient demographics are listed in Table 1. Arrows indicate bronchial smooth muscle [17]. (b) Quantification of Alp1 in bronchial smooth muscle bundles correlated with impairment of lung function; ** p = 0.003, Mann–Whitney.
