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Average plasma concentrations versus time of 5-FU and 5-FU-NCM after oral administration in rats. The initial dose given to SD rats was based on their body weight at the rate of 0.06 mmol/kg. Blood samples were collected at 1, 5, 10, 15, 20, 30, 60, 90, and 120 min after administration. x̅ ± SD, n = 8, ** p < 0.01, two-way ANOVA.
