Table 3. Major Pharmacokinetic Parameters of 5-FU-NCM^a.

parameters	unit	5-FU	5-FU-NCM
t1/2α	h	0.064 ± 0.013	0.197 ± 0.05
t1/2β	h	0.302 ± 0.062	0.229 ± 0.041
V1/F	L/kg	2.783 ± 0.915	0.974 ± 0.442
CL/F	L/h/kg	11.845 ± 0.239	4.27 ± 0.165
AUC (0 – t)	μmol/L h	4.928 ± 0.076	14.017 ± 0.520
AUC (0 – ∞)	μmol/L h	5.067 ± 0.104	14.071 ± 0.528
Tmax	h	0.333	0.250
Cmax	μmol/L	7.993 ± 0.375	21.910 ± 0.872

^aDifferent parameters were measured as listed (x̅ ± s, n = 8).