Table 1.
Temporal Sequence of a Typical Trial
| 2 months before quarantine |
| Eligibility screening |
| Blood sample for preexisting antibody to virusa |
| 1–4 weeks before quarantine |
| Psychosocial questionnaires (Session 1) and interviews |
| Demographic questionnaire |
| 6–14 daily assessments of risky behaviors & social interactionsb |
| Biomarker assessmentsb |
| Quarantine Day 0 |
| Psychosocial questionnaires (Session 2) |
| Baseline nasal secretions for virus culture |
| Baseline signs and symptoms of respiratory illness |
| End of Day 0 |
| Inoculation with virus |
| Quarantine Days 1 through 5–6 |
| Daily nasal secretions for virus culture |
| Daily signs and symptoms of respiratory illness |
| 4 weeks after virus challenge |
| Postexposure blood sample for antibody to virus |
a
In some trials, preexisting antibody levels were assessed on Quarantine Day 0 before the viral challenge.
b
Biomarker assessments were performed in select trials.