. Author manuscript; available in PMC: 2021 Jul 1.

Published in final edited form as: Genet Epidemiol. 2020 Apr 27;44(5):408–424. doi: 10.1002/gepi.22296

Table 3.

Summary of mediation model fit to DNA methylation and reactive cortisol stress following childhood trauma, along with univariate Sobel tests for mediation, which ignores correlation among mediators.

Mediator (gene)	$\hat{α}$	$S E (\hat{α})$	$\hat{β}$	$S E (\hat{β})$	$\hat{α} \times \hat{β}$	Univariate Sobel Test p-value
cg01644731 (CTDSP2)	0.32	0.10	−0.30	0.09	−0.09	0.037
cg06890779 (ATF7IP2)	−0.37	0.10	0.14	0.09	−0.05	0.100
cg25626453 (PRRC2A)	−0.−29	0.10	0.37	0.09	−0.11	0.038
cg26801646 (VDAC2)	−0.32	0.10	0.28	0.09	−0.09	0.039

Total $\hat{α} \times \hat{β}$					−0.34
					0.07	$(S E (\hat{δ}) = 0.10)$

Grand Total					−0.27

$c o r (x, y)$					−0.27
$v_{x} = 1.00$
${\hat{v}}_{y} = 0.63$
$(S E ({\hat{v}}_{y}) = 0.10)$