Table 2.

Top statistically related signaling pathways to miR-584 targetome obtained from KEGG database through DAVID tool

Rank	KEGG Pathway	Number of genes (%)	P*
1	Pathways in cancer	21 (2.9)	5.4E­2
2	Regulation of actin cytoskeleton	19 (2.6)	3.4E­3
3	Focal adhesion	17 (2.4)	9.1E­3
4	Ubiquitin mediated proteolysis	15 (2.1)	1.6E­3
5	Chemokine signaling pathway	14 (1.9)	4.7E­2
6	Endocytosis	13 (1.8)	8.1E­2
7	Fc gamma R­mediated phagocytosis	12 ()	1.8E­3
8	Chronic myeloid leukemia	11 (1.7)	9.9E­4
9	Insulin signaling pathway	11 (1.5)	5.4E­2
10	Wnt signaling pathway	11 (1.5)	9.8E­2
11	Pancreatic cancer	10 (1.4)	2.8E­3
12	Adherens junction	10 (1.4)	4.4E­3
13	Vascular smooth muscle contraction	9 (1.2)	9.4E­2
14	Colorectal cancer	9 (1.2)	2.3E­2
15	TGF­beta signaling pathway	9 (1.2)	2.8E­2
16	Oocyte meiosis	9 (1.2)	8.7E­2
17	Long­term potentiation	8 (1.1)	2.2E­2
18	Phosphatidylinositol signaling system	8 (1.1)	3.4E­2
19	Endometrial cancer	7 (1)	2.0E­2
20	Acute myeloid leukemia	7 (1)	3.3E­2
21	Melanoma	7 (1)	7.4E­2
22	B cell receptor signaling pathway	7 (1)	9.1E­2
23	VEGF signaling pathway	7 (1)	9.1E­2
24	Non­small cell lung cancer	6 (0.8)	7.3E­2
25	Dorso­ventral axis formation	4 (0.6)	8.4E­2

* The threshold of EASE score, a modified Fisher Exact P-value, for gene-enrichment analysis