Table 1.

The role and regulation of STAT3 in different cancers.

Cancer Type	Signaling Network	Effect on STAT3	Results	Refs
Breast cancer	BHLH40-AS1/IL-6/STAT3	Induction	Promoting progression and proliferation	[60]
	IL-6/STAT3	Induction	Radiation induces STAT3-mediated inflammation and radio resistance	[61]
	MiR-454/VGLL4/STAT3	Induction	MiR-454 induces the STAT3 signaling pathway via VGLL4 downregulation, leading to cancer malignancy	[62]
	PAK1/STAT3	Induction	Stimulation of the nuclear translocation of STAT3 and enhancing breast cancer stem cell proliferation	[63]
	SIRT4/IL-6/STAT3	Inhibition	Sensitizing cancer cells to tamoxifen chemotherapy	[64]
Prostate cancer	IL-8/STAT3/MALAT1	Induction	STAT3 upregulates the expression of MALAT1, leading to progression and proliferation	[65]
	MiR-17/JAK/STAT3	Inhibition	MiR-17 reduces the expression of pro-survival factors, such as Bcl-2, and induces apoptosis via STAT3 downregulation	[66]
Bladder cancer	MiR-4500/STAT3/CCR7	Inhibition	Suppressing migration and proliferation	[67]
	CD44/Akt/ERK/STAT3	Induction	Inhibition of apoptosis and cell cycle arrest	[68]
Lung cancer	B7-H4/PD-1/STAT3	Induction	Promoting proliferation and invasion via immune evasion	[69]
	KCP10043F/STAT3	Inhibition	Induction of apoptotic cell death	[70]
	BIS/STAT3	Induction	Reducing sensitivity of cancer cells to digoxin-mediated migration and growth inhibition	[71]
Glioblastoma	Annexin-A2/STAT3/oncostatin M receptor	Induction	Promoting the proliferation and invasion of cancer cells	[72]
	Hsa-miR-181d/STAT3	Inhibition	Garcinol upregulates the expression of hsa-miR-181d to inhibit STAT3 and the malignancy of cancer cells	[73]
	TROP2/JAK2/STAT3	Induction	Promoting proliferation and migration	[74]
	Bradykinin B1 receptor/STAT3/IL-8	Induction	Enhancing malignant behavior	[75]