Table 3.
The regulation of STAT3 by miRs in gastric cancer.
| MiiR | MiR Type | Cancer Cell Line | Effect on STAT3 | Major Outcomes | Refs |
|---|---|---|---|---|---|
| MiR-143 | Onco-suppressor | GC cell lines (AGS, SNU-1, SNU-5, SNU-16, NCIN87 and KATOIII) | Downregulation | Disrupting the proliferation and invasion of cancer cells | [96] |
| MiR-125a | Onco-suppressor | Human GC cell lines MKN45, SGC7901 and NCI-N87 | Downregulation | Reducing the expression of HAS1 and interfering with the migration of cancer cells | [99] |
| MiR-375 | Onco-suppressor | Human GC cell lines BGC-823, AGS, SGC-7901 and MKN-45 | Downregulation | Inhibiting proliferation and migration via STAT3 downregulation | [105] |
| MiR-148a | Onco-suppressor | GC cell lines SNU-1 (ATCC: CRL-5971), SNU-16 (ATCC: CRL-5974), AGS (ATCC: CRL-1739), NCI-N87 (ATCC: CRL-5822) and KATOIII (ATCC: HTB-103) | Downregulation | Suppressing growth and metastasis by the downregulation of CCK-BR via STAT3 downregulation | [108] |
| MiR-874 | Onco-suppressor | Human GC cell lines AGS and BGC823, MKN28 and SGC-7901, as well as the human normal gastric epithelial cell line GES-1 | Downregulation | Disrupting the STAT3/VEGF axis Inhibition of angiogenesis and the malignancy of cancer cells |
[117] |
| MiR-216a | Onco-suppressor | Normal human gastric epithelium cell line (GES-1) and GC cell lines (SGC-7901, MGC-803, MKN-28 and BGC-823) | Downregulation | Suppressing the metastasis of cancer cells via disrupting the STAT3/EMT axis | [121] |
| MiR-93-5p | Oncogene | AGS and HEK293 cells | Upregulation | Downregulation of the STAT3/MMP-9 axis Inhibition of metastasis and invasion |
[127] |
| MiR-18a | Oncogene | Human GAC cell lines MKN28 and MKN1 | Upregulation | STAT3 induction Promoting the malignant behavior of cancer cells |
[131] |
| MiR-155 | Oncogene | Human GC cell lines BGC-823, NCI-N87, SGC-7901, AGS, MKN-45 and immortalized gastric mucosa epithelial cell line GES-1 | Upregulation | Stimulation of STAT3 Activation of MMP-2 and MMP-9 Enhancing invasion and migration of cancer cells |
[132] |
| MiR-106a-3p | Oncogene | Human GC cell line including SGC-7901 and BGC-823 | Upregulation | Stimulation of aptinib resistance Activation of JAK2/STAT3 signaling SOCS2, SOCS4 and SOCS5 downregulation |
[133] |