Table 5.
lncRNAs as upstream modulators of STAT3 signaling pathway in GC cells.
| lncRNA | Type of lncRNA | Downstream Signaling | Cell Line | Effect on STAT3 | Major Results | Refs |
|---|---|---|---|---|---|---|
| SNHG16 | Oncogene | MiR-135a/JAK2/STAT3 | Four GC cell lines (BGC823, MGC803, MKN45, SGC7901) and normal GC cell line GES-1 | Induction | Promoting colony formation and the proliferation of cancer cells Inhibition of apoptosis |
[222] |
| HOTAIR | Oncogene | MiR-454-3p/STAT3/cyclin D1 | AGS and SGC7901 cells | Induction | Knock-down of HOTAIR Sensitizing cancer cells to apoptosis Upregulation of miR-454-3p and the subsequent inhibition of the STAT3/cyclin D1 axis |
[216] |
| PVT1 | Oncogene | STAT3/VEGF | GES-1, SGC-7901, BGC-823, MNK-45, AGS, SUN-638, HGC-27 and HUVEC | Induction | Promoting angiogenesis and the growth of cancer cells | [219] |
| NEAT1 | Oncogene | MiR-506/STAT3 | BGC823, SGC-7901, AGS, MGC803, MKN28 cells, GES-1 and HEK-293T cells | Induction | Sponging miR-506 Enhancing expression of STAT3 Increasing the malignancy of cancer cells |
[220] |
| GACAT3 | Oncogene | IL-6/STAT3 | Human GC cell lines HGC-27 and SGC-7901 | Induction | Enhancing the proliferation of cancer cells in an inflammatory response behavior | [221] |
| HOXD-AS1 | Oncogene | JAK2/STAT3 | Human GC cell lines (SGC-7901, BGC-823, MGC803 and MKN-45) | Induction | Silencing of HOXD-AS1 is correlated with the downregulation of STAT3 and growth inhibition | [223] |