Table 6.

Molecular pathways targeting STAT3 in GC cells.

Signaling Network	Cell Line	Effect on STAT3	Results	Refs
CXCR4/JAK2/STAT3/VEGF	Human SGC-7901 and MKN45 cells	Induction	Induction of VEGF by CXCR4 Subsequent activation of JAK2/STAT3 Enhancing the migration and proliferation of cancer cells	[285]
NOX4/JAK2/STAT3/EMT	Six human GC cell lines (MKN-45, SGC-7901, MGC-803, BGC-823, MKN-28 and AGS)	Induction	Induction of JAK2/STAT3 by NOX4 Stimulation of EMT Promoting invasion	[286]
DC-SIGNR	Human GC cell lines, SGC-7901, MGC-803, BGC-823 and AGS, and the control gastric epithelial cell line GES-1	Induction	Ensuring the growth and viability of cancer cells by the induction of the JAK2/STAT3 pathway	[287]
HOXA11	GC cell lines (KATO III, NCI-N87, SNU-16, AGS and SNU-16) and HEK 293T	Induction	Promoting the stemness and migration of cancer cells by the stimulation of STAT3	[288]
TFF1/STAT3	AGS cells	Induction	Enhancing the proliferation and migration of cancer cells	[67]
DARPP-32/IGF-1R/STAT3	AGS cells	Induction	Promoting proliferation and invasion	[289]
BMX-ARHGAP/STAT3	Four human GC cell lines (SNU-5, MNK-45, AGS and SGC7901) and the normal gastric epithelial cell line (GES-1)	Induction	Maintaining the carcinogenesis ability of GC stem cells	[279]
CXCL16/STAT3/Ror1	MKN45, MKN45-Luc and KATOIII cells	Induction	Increasing progression and malignancy	[290]
Complement C3/JAK2/STAT3	Human SGC-7901 and MGC-803 cells, normal gastric epithelial cells (GES-1)	Induction	Poor prognosis and enhanced proliferation of cancer cells	[291]
BTF3/JAK2/STAT3/EMT	Human gastric epithelial cell line GES-1 and human GC cell lines, including AGS, HGC-27, MKN-28, MGC-803 and SGC-7901 cells	Induction	Induction of JAK2/STAT3 by BTF3 Stimulation of EMT Enhancing the proliferation and migration of cancer cells	[292]
IGF1/IGF1R/STAT3/IFITM2	GC cell lines	Induction	Enhancing the growth and metastasis of cancer cells	[293]
IL-6/JAK2/STAT3	GC cell lines SNU-1, MKN45, SGC7901 and MKN28	Induction	Secretion of IL-6 by CAMs Stimulation of JAK2/STAT3 by IL-6	[294]
TNF-α/IL-6/STAT3	SGC7901 cells	Induction	Induction of EMT Ensuring the metastasis of cancer cells	[295]
Succinate/STAT3/VEGF	Human gastric mucosal epithelial cell line GES-1 and human GC cell lines AGS (low-differentiated human gastric adenocarcinoma), NCI-N87 (well-differentiated human carcinoma), BGC-823 (low-differentiated human gastric adenocarcinoma) and SGC-7901 (moderate-differentiated human gastric adenocarcinoma)	Induction	Induction of VEGF by succinate via STAT3 overexpression Increasing viability and invasion of cancer cells	[296]
Cyclophilin B/STAT3/miR-520d-5p	GC cell lines	Induction	There is feedback consisting of the downregulation of miR-520d-5p and upregulation of cyclophilin B and STAT3, leading to the enhanced growth of cancer cells	[297]
CMTM3/STAT3/Twist1/EMT	Human GC cell line SGC-7901	Inhibition	Downregulation of STAT3 by CMTM3 Suppressing metastasis	[298]
HCCR/STAT3	Human GC cell lines AGS, MKN-45, BGC823, MGC803, HGC27, SGC7901, NCI-N87	Induction	Triggering chemoresistance	[299]
GRIM19/STAT3	Immortalized normal gastric epithelial cell line GES-1, human embryonic kidney HEK-293 cells, human GC SGC-7901 and BGC-823 cell lines	Inhibition	Suppressing STAT3 Induction of apoptosis	[300]
ROS/IL-6/STAT3	AGS cells	Induction	Enhanced generation of ROS by H. pylori Stimulation of IL-6/STAT3 Enhanced proliferation and invasion of cancer cells	[301]
IL-6/STAT3/VEGF	GC cell lines including SGC-7901, MGC, MKN-28 and AGS	Induction	Promoting invasion and angiogenesis Induction of STAT3 and subsequent activation of VEGF	[302]
IL-17/STAT3/VEGF	Human GC (AGS) cells and other cells SGC7901, MKN 45 and BGC823	Induction	Enhancing growth Induction of angiogenesis Activation of STAT3/VEGF	[303]