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. 2020 Jun 30;2020:4126913. doi: 10.1155/2020/4126913

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Copyright © 2020 Fajiang Xie et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fasudil inhibited M1 macrophage polarization and proinflammatory cytokines in renal tissues of diabetic mice. (a) Representative immunohistochemical staining of CD11c (a marker for M1 macrophages; red arrows), IL-6, and TNF-α in renal tissues. (b) Quantitative analysis for the number of M1 macrophages in renal tissue specimens. Data are expressed as mean ± SD, ∗P < 0.05 vs. the Ctrl group; ^#P < 0.05 vs. the DM group. (c) Quantitative analysis of the protein expression of IL-6 in renal tissue specimens. Data are expressed as mean ± SD, ∗P < 0.05 vs. the Ctrl group; ^#P < 0.05 vs. DM group. (d) Quantitative analysis of the protein expression of TNF-α in renal tissue specimens. Data are expressed as mean ± SD, ∗P < 0.05 vs. the Ctrl group; ^#P < 0.05 vs. the DM group.