Figure 4.

Fasudil increased M2 macrophage polarization and anti-inflammatory cytokines in renal tissues of diabetic mice. (a) Representative immunohistochemical staining of CD206 (a marker for M2 macrophages; red arrows) and IL-10 in renal tissues. (b) Quantitative analysis for the number of M2 macrophages in renal tissue specimens. Data are expressed as mean ± SD, ∗P < 0.05 vs. the Ctrl group; ^#P < 0.05 vs. the DM group. (c) Quantitative analysis of the protein expression of IL-10 in renal tissue specimens. Data are expressed as mean ± SD, ∗P < 0.05 vs. the Ctrl group; ^#P < 0.05 vs. the DM group.