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. 2020 Jun 18;9(6):336. doi: 10.3390/antibiotics9060336

Table 18.

Results of checkerboard assays of colistin in combination with resveratrol from Cannatelli et al. (2018) [120].

Strains Phenotype Colistin MICs (µg/mL) at Different Resveratrol Concentrations (µg/mL)
Resveratrol Concentration (µg/mL)
0 8 16 32 64 128 256
E. coli LC711/14 COL-R 8 4 2 * 1 * 0.25 * 0.25 * 0.125 *
E. coli LC761/12 COL-R 4 0.5 * 0.5 0.25 * 0.125 * 0.125 * 0.125 *
E. coli FI-4451 COL-R 8 8 8 4 4 4 4
E. coli FI-4531 COL-R 8 4 4 4 4 2 * 2 *
E. coli FI-4592 COL-R 8 4 4 4 4 4 4
E. coli LC902/14 COL-R 8 4 4 4 4 2 * 2 *
C. braakii CA-26 COL-R 8 4 4 4 4 2 * 2 *
S. maltophilia 157 COL-R 32 4 2 * 1 * 0.5 * 0.125 * 0.125 *
E. cloacae CIP6085 COL-R 128 128 32 * 8 * 0.5 * 0.25 * 0.125 *
K. pneumoniae KKBO-1 a MDR/ COL-S 0.5 0.5 0.5 0.5 0.5 * 0.5 0.5
K. pneumoniae KKBO-4 MDR/ COL-R 64 64 64 16 * 8 * 4 * 4 *
K. pneumoniae KPB-1 a MDR/ COL-S 0.5 0.5 0.5 0.5 0.5 0.5 0.5
K. pneumoniae KPB-2 MDR/ COL-R 4 4 4 4 2 1 * 0.5 *
K. pneumoniae KK207-1 a MDR/COL-S 0.5 0.5 0.5 1 0.5 0.5 0.5
K. pneumoniae KK207-2 MDR/ COL-R 64 64 64 64 4 * 1 * 0.5 *
K. pneumoniae 6884 MDR/ COL-R 8 8 8 8 4 * 1 * 1 *
K. pneumoniae KPFan b COL-R 32 32 16 8 * 2 * 1 * 1 *
K. pneumoniae KPGP1 b COL-R 32 32 32 32 2 * 1 * 1 *
A. Baumanii N50 MDR/COL-R 64 64 64 64 8 * 1 * 1 *
S. marcescens CCUG1647T COL-R >128 >128 >128 >128 16 * 1 * 1 *
P. mirabilis NO-051 COL-R >128 >128 >128 >128 >128 >128 8 *

a These strains were the colistin-susceptible (COL-S) precursors of colistin-resistant (COL-R) K. pneumoniae KKBO-4, K. pneumoniae KPB-2, and K. pneumoniae KK207-2 strains, respectively. Resveratrol MICs were > 512 mg/L for all tested strains. b These COL-R strains were selected in vitro, using two COL-S precursors. Multidrug-resistant phenotypes (MDR) refer to strains resistant to carbapenems (imipenem and meropenem), ciprofloxacin, and amikacin. * Combinations in which colistin/resveratrol combinations yielded a synergistic activity (FICI ≤ 0.5). The lower concentration of resveratrol needed for restoring susceptibility to colistin is shaded in gray.