Table 3.
Significant Regions of Activation for (A) SCZ-Rel > HC and (B) SCZ-Rel < HC (Thresholded at P < .005; FWHM 20 mm)
| Region | BAa | x | y | z | SDM-Z | P | Voxelsb | Jackknife |
|---|---|---|---|---|---|---|---|---|
| (A) SCZ-Rel > HC | ||||||||
| R Precuneus | 7/19 | 16 | −74 | 36 | 1.523 | 2.017e-4 | 887 | 77c |
| R Longitudinal fasciculus /insula | 28 | 16 | 6 | 1.115 | 3.373e-3 | 130 | 55 | |
| (B) SCZ-Rel < HC | ||||||||
| R Posterior cingulate gyrus | 23 | 2 | −24 | 34 | −1.364 | 2.083e-3 | 344 | 77c |
| L Insula | 13(48) | −32 | −24 | 4 | −1.387 | 1.835e-3 | 183 | 77c |
| R Middle temporal gyrus | 22 | 56 | −44 | 8 | −1.428 | 1.403e-3 | 149 | 77c |
Note: SCZ-Rel = adolescent relatives of schizophrenia patients; HC = healthy controls; BA = Brodmann area; apeak coordinates with overlapping BA areas (in brackets); b2 mm × 2mm × 2mm; SDM-Z = signed differential mapping z-score; Jackknife replicability is represented as percentage; L = Left; R = Right; foci represented in MNI space; cregions greater than 75% replicability.