Table 2.

Study design, settings, population included and study focus in relation with microbiome (CPPS—chronic pelvic pain syndrome, UTI—urinary tract infection, LUTS—lower urinary tract symptoms, HTN—arterial hypertension, AKI—acute kidney injury).

Author	Study Focus Related to Microbiome	N	Males	Females	Single Site/Multicentric + Country	Controlled/Non-Controlled
Lewis, 2013 [19]	Healthy population	16	6	10	Single center—UK	Non-controlled
Pearce, 2015 [20]	Women with urge urinary incontinence	182	0	182	Single center—USA	Non-controlled
Shoskes, 2016 [21]	Chronic prostatitis, CPPS	50	50	0	Single center—USA	Controlled
Karstens,2016 [22]	Urge incontinence	20	0	20	Single center—USA	Controlled
Abernethy, 2017 [23]	Interstitial cystitis	40	0	40	Single center—USA	Controlled
Modena, 2017 [24]	Kidney transplant patients	48	30	18	Single center—USA	Controlled
Rani, 2017 [25]	Kidney transplant patients	29	18	11	Single center—USA	Controlled
Komesu, 2017 [26]	Urinary incontinence	210	0	210	Multicenter—USA	Controlled
Curtiss,2017 [27]	Overactive bladder	98	0	98	Single center—UK	Controlled
Adebayo, 2017 [28]	Urogenital schistosomiasis	70	36	34	Single center—Nigeria	Non-controlled
Gotschick, 2017 [29]	Bacterial vaginosis	123	31	92	Single center—Germany	Controlled
Wu, 2017 [30]	Overactive bladder and psychological factors	55	0	55	Single center—China	Controlled
Shrestha, 2018 [31]	Males with/without biopsy for diagnosis of prostate cancer	135	135	0	Single center—USA	Controlled
Wu, 2017 [32]	Bladder cancer	60	60	0	Single center—China	Controlled
Chen, 2018 [33]	Urge incontinence/detrusor overactivity and recurrent UTI	39	0	39	Single center—Australia	Non-controlled
Fok, 2018 [34]	LUTS on females	126	0	126	Single center—USA	Non-controlled
Wu, 2018 [35]	Kidney transplant graft dysfunction	67	19	48	Multicenter—USA	Controlled
Komesu, 2018 [36]	Mixed urinary incontinence	212	0	212	Multicenter—USA	Controlled
Koedooder, 2018 [37]	In vitro fertilization	350	0	350	Single center—The Netherlands	Controlled
Mai, 2019 [38]	Bladder cancer	24	18	6	Single center—China	Non-controlled
Alanee, 2019 [39]	Prostate cancer	30	30	0	Single center—USA	Controlled
Dornbier, 2019 [40]	Urinary calcium stones	52	23	29	Single center—USA	Non-controlled
Moynihan, 2019 [41]	Hematuria/tobacco smoke	43	43	0	Single center—USA	Non-controlled
Shannon, 2019 [42]	Bladder urinary oxygen tension	34	0	34	Single center—USA	Non-controlled
Alanee, 2019 [43]	Transrectal biopsy	30	30	0	Single center—USA	Controlled
Kassiri, 2019 [44]	Relation between pediatric gastrointestinal and urinary microbiome	10	10	0	Single center—USA	Controlled
Bresler, 2019 [45]	Interstitial cystitis	41	0	41	Single center—USA	Controlled
Wolff, 2019 [46]	Oral probiotics for UTI	7	0	7	Single center—USA	Controlled
Colas, 2020 [47]	Kidney transplant	98	59	39	Single center—France	Controlled
Price, 2020 [48]	Continent adult women	224	0	224	Single center—USA	Non-controlled
Pohl, 2020 [49]	Differentiation between urine collection method	20	14	6	Single center—USA	Non-controlled
Hourigan, 2020 [50]	Bladder cancer—urine collection: midstream vs. cystoscopy	22	14	8	Single center—USA	Non-controlled
Xie, 2020 [51]	Calcium kidney stones	43	43	0	Single center—China	Non-controlled
Bajic, 2020 [52]	Male LUTS with/without surgery	49	49	0	Single center—USA	Controlled
Liu, 2020 [53]	Kidney stone and HTN (pelvis urine)	62	42	20	Single center—China	Controlled
Gerges-Knafl, 2020 [54]	Transplant vs. non-transplant AKI	30	16	14	Single center—Australia	Controlled
Wu, 2020 [55]	Chronic prostatitis	63	63	0	Single center—China	Controlled
Thomas -White, 2016 [56]	Stress urinary incontinence	197	0	197	Multicentric—USA	Controlled