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. 2020 May 6;9(2):13. doi: 10.3390/antib9020013

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© 2020 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Generation of structural diversity in the humoral immune system. Beyond the bone marrow, multidirectional growth towards antigenic shapes generates diversity in the system, further enlarging that of the naïve repertoire. The energy of these interactions is adjusted for each antigen based on its immunological properties, thereby secreted antibodies can adjust the concentration of the target antigen in the host. *somatic hypermutations; CLP, common lymphoid progenitor; immat., immature; nB2, naive B2 cell; MBC, memory B cell; PC, plasma cell; BCR, B-cell receptor.