Table 1.
circRNA-miRNA-mRNA/protein network in GC.
| Circular RNAs | Expression | Parental gene | Sponged miRNA | Targeted mRNA/protein | Related cell behaviors | Ref |
|---|---|---|---|---|---|---|
| hsa_circ_0006282 | Up | / | miR-155 | FBXO22 | Proliferation, metastasis | [105] |
| hsa_circ_000684 | Up | / | miR-186 | ZEB1 | Proliferation, migration, invasion, tube formation | [106] |
| hsa_circRNA_001569 | Up | / | miR-145 | NR4A2 | Proliferation, apoptosis, | [107] |
| hsa_circRNA_102958 | Up | / | miR-585 | CDC25B | Proliferation, migration, invasion, | [108] |
| hsa_circRNA_104433 | Up | ARPC1B | miR-497-5p | CDC25A | Proliferation, apoptosis | [109] |
| hsa_circ_0000291 | Up | CD44 | miR-183 | ITGB1 | Proliferation, migration | [110] |
| hsa_circ_0017639 | Up | SFMBT2 | miR-224-5p | USP3 | Proliferation, migration | [111] |
| hsa_circ_0092306 | Up | chr 11 | miR-197-3p | PRKCB | Proliferation, apoptosis, migration, invasion, | [112] |
| Circ-ATAD1 | Up | ATAD1 | miR-140-3p | YY1/PCIF1 | Proliferation, apoptosis, migration, invasion | [88] |
| Circ-ATXN7 | Up | ATXN7 | miR-4319 | ENTPD4 | Proliferation, apoptosis, migration | [113] |
| circ-PIP5K1A | Up | PIP5K1A | miR-671-5p | KRT80 | Proliferation, migration, invasion, EMT process | [34] |
| circ-ERBB2 | Up | ERBB2 | miR-503,miR-637 | CACUL1, MMP-19 | Proliferation, apoptosis, migration, invasion | [46] |
| circ-NHSL1 | Up | NHSL1 | miR-1306-3p | SIX1/vimentin | Migration, invasion | [45] |
| circ-PVT1 | Up | PVT1 | miR-125b | E2F2 | Proliferation | [43] |
| circ-HIPK3 | Up | HIPK3 | miR-124/29b | COL1A1/COL4A1/CDK6 | Proliferation | [41] |
| circ-OSBPL10 | Up | OSBPL10 | miR-136-5p | WNT2 | Proliferation, migration, invasion | [40] |
| circ-NOTCH1 | Up | NOTCH | miR-449c-5p | MYC/NOTCH1 | Proliferation, migration, invasion | [42] |
| circ-NRIP1 | Up | NRIP1 | miR-149-5p | AKT1/mTOR pathway | Proliferation, migration, invasion | [36] |
| ciRS-7 | Up | Cdr1as | miR-7 | PTEN/PI3K/AKT pathway | Proliferation, migration, invasion | [32] |
| circ-MAN2B2 | Up | MAN2R2 | miR-145 | PI3K/AKT/JNK pathway | Proliferation, migration | [35] |
| circ-HIAT1 | Down | HIAT1 | miR-21 | PTEN/PI3K/AKT/ERK pathway | Proliferation, apoptosis, EMT process | [33] |
| circ-ZFR | Down | ZFR | miR-130a/107 | PTEN | Proliferation, apoptosis | [38] |
| circ-YAP1 | Down | YAP1 | miR-367-5p | p27 Kip1 | Proliferation, invasion | [114] |
| circ-RHOBTB3 | Down | RHOBTB3 | miR-654-3p | p21 | Proliferation, apoptosis | [115] |
| circ-LARP4 | Down | LARP4 | miR-424-5p | LATS1 | Proliferation, invasion | [90] |
| circ-FAT1 (e2) | Down | FAT1 | miR-548 g | RUNX1 | Proliferation, invasion, migration. | [52] |
| circ-CCDC9 | Down | CCDC9 | miR-6792-3p | CAV1 | Proliferation, migration, invasion | [116] |
| hsa_circ_0001368 | Down | KLHL24 | miR-6506-5p | FOXO3 | Proliferation, invasion | [117] |