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. 2020 May 24;12(11):10162–10179. doi: 10.18632/aging.103336

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Copyright © 2020 Ózsvári et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A CSC-based mitochondrial 4-gene signature predicts distant metastasis and tumor recurrence in ER(+) breast cancer patients. To optimize its predictive value, we constructed a short 4-gene signature, which revealed an increase in prognostic value, related to distant metastasis (HR=1.91; P=2.2e-08). This 4-gene signature was also able to predict tumor recurrence in the same patient population (HR=1.68; P=1.2e-15). See also Supplementary Tables 2 and 3 and 3. Therefore, these CSC-based mitochondrial signatures may provide a new prognostic approach for predicting treatment failure in breast cancer patients. DMFS, distant metastasis free survival; RFS, relapse free survival.