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. 2020 Jun 4;12(11):10381–10397. doi: 10.18632/aging.103264

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Copyright © 2020 Jin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Pathway analysis of the differentially-expressed proteins. (A) Pathway analysis of significantly altered metabolites in A549 cells compared with baseline. (B and C) Compound reaction networks of the metabolites and genes were visualized using Metscape: genes (circles), metabolic enzymes (squares) are presented as nodes, and relationships are presented as edges. Input genes are shown in blue, input metabolites are shown in red. The metabolite-gene association network was primarily related to malate-aspartate metabolism.