Figure 3.

Adult specific overexpression of Ldh shortens fly lifespan. (A–F) Survival curves of adult males overexpressing Ldh in all clock cells via tim^ts (A, D), in neurons via elav^ts (B, E), or in glia via repo^ts (C, F) each graphed relative to their control group at 27°C and 25°C, respectively. Overexpression of Ldh via each driver resulted in decreased median lifespan compared to their respective controls in both 27°C and 25°C (Gehan-Breslow-Wilcoxon test; p<0.05 for graphs B and C and p<0.0001 for graphs A, D, E, and F). See Supporting Information Supplementary Table 2 for experimental details.