Table 1B. Common exon variants in the ACE2 gene in different populations.

Variant ID	Consequence	A1/N alleles ITA	Freq ITA	A1/N alleles EUR	Freq EUR	A1/N alleles EAS	Freq EAS	ITA Vs EUR	ITA Vs EAS	EUR Vs EAS
rs2285666	c.439+4G>A	909/4408	0.206	17240/86164	0.200	7336/13387	0.548	0.331	P<2.2e-16	P<2.2e-16
rs35803318	p.Val749Val	235/4422	0.053	3935/88946	0.044	0/13918	0.0	P=0.0058	P<2.2e-16	P<2.2e-16

Total allele counts, carrier allele counts, and carrier frequencies are shown; only variants with MAF more than 5% were considered.

P values are presented as non-corrected; the number of statistical comparisons performed in Tables 1A, 1B, 2A, and 2B is collectively of 24, thus lowering the threshold for significance at P=0.0021 (Bonferroni threshold). Significant P values are indicated in bold.

A1: alleles carrying variants; Freq A1: frequency of A1 allele; ITA: Italian population; EUR: European population; EAS: East Asian population.