Table 2B. Common exon variants in the TMPRSS2 gene in different populations.

Variant ID	Consequence	A1/N alleles ITA	Freq ITA	A1/N alleles EUR	Freq EUR	A1/N alleles EAS	Freq EAS	ITA Vs EUR	ITA Vs EAS	EUR Vs EAS
rs2298659	p.Gly259Gly	1388/7968	0.174	28744/122880	0.234	5179/19478	0.266	P<2.2e-16	P<2.2e-16	P<2.2e-16
rs17854725	p.Ile256Ile	4131/7968	0.518	67712/122814	0.551	2544/19604	0.130	P=1.16e-08	P<2.2e-16	P<2.2e-16
rs12329760	p.Val160Met	1387/7968	0.174	29831/128604	0.232	7651/19934	0.384	P<2.2e-16	P<2.2e-16	P<2.2e-16
rs3787950	p.Thr75Thr	889/7968	0.112	9864/127666	0.077	2905/19600	0.148	P<2.2e-16	P=1.39e-15	P<2.2e-16

Total allele counts, carrier allele counts, and carrier frequencies are shown; only variants with MAF more than 5% were considered.

P values are presented as non-corrected; the number of statistical comparisons performed in Tables 1A, 1B, 2A, and 2B is collectively of 24, thus lowering the threshold for significance at P=0.0021 (Bonferroni threshold). Significant P values are indicated in bold.

A1: alleles carrying variants; Freq A1: frequency of A1 allele; ITA: Italian population; EUR: European population; EAS: East Asian population.