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Binding studies of Compounds 1 and 5 with SphK1. Fluorescence emission spectra of SphK1 with increasing concentrations of (A) compound 1 (0–36 μM) and (B) compound 5 (0–31.1 μM). SphK1 was excited at 280 nm, and emission spectra were recorded in the range of 300–400 nm. Modified Stern–Volmer plot showing quenching of SphK1 fluorescence with increasing concentration of (C) Compound 1 and (D) Compound 5.
