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Structural representation of the binding pattern of Compounds 1, 5, and 7 along with PF-543 in the substrate-binding site cavity of SphK1. (A) Cartoon representation of SphK1 showing ligands bound to the active site cavity. (B) Interaction of Compounds 1, 5, and 7 to the SphK1 residues. (C) Surface model highlighting the active site pocket of SphK1.
