Table 1.
Anthropometric and biochemical parameters in healthy donors, NAFL, and NASH patients.
| Parameters | Healthy donors (10) | NAFL (10) | NASH (20) | P value (NASH vs. healthy donors) | P value (NASH vs. NAFL) |
|---|---|---|---|---|---|
| Age (years) | 54 ± 6.9 | 57.6 ± 7.2 | 56.3 ± 11.2 | 0.1682 | 0.8655 |
| Sex (F/M) | 5/5 | 4/6 | 12/8 | ||
| Weight (kg) | 68.75 ± 5.3 | 69.4 ± 8.3 | 88.7 ± 17.3 | <0.0001 | <0.0001 |
| BMI (kg/m2) | 22.4 ± 1.68 | 23.0 ± 1.7 | 32.4 ± 4.7 | <0.0001 | <0.0001 |
| AST (UI/mL) | 11.2 ± 5.5 | 20.4 ± 6.5 | 30.7 ± 11.3 | 0.0046 | 0.0007 |
| ALT (UI/mL) | 12.1 ± 4.04 | 26.1 ± 5.53 | 62.8 ± 30.2 | 0.0006 | 0.0005 |
| GGT (UI/mL) | 18.52 ± 5.58 | 23.9 ± 7.39 | 61.2 ± 20.2 | <0.0001 | <0.0001 |
| Total cholesterol (mg/dL) | 161 ± 15.5 | 172.9 ± 24.1 | 212 ± 25.9 | <0.0001 | <0.0001 |
| LDL cholesterol (mg/dL) | 100.6 ± 20.9 | 109.7 ± 33.8 | 125 ± 19.5 | 0.0432 | 0.0339 |
| HDL cholesterol (mg/dL) | 48.0 ± 8.1 | 47.6 ± 7.3 | 46.8 ± 9.9 | 0.7802 | 0.1406 |
| Triglycerides (mg/dL) | 100.8 ± 25.7 | 101.8 ± 33.2 | 117.3 ± 67.4 | 0.0169 | 0.0004 |
| Glucose (mg/dL) | 85.4 ± 10.0 | 92.2 ± 7.6 | 99.8 ± 16.5 | 0.0264 | 0.0173 |
| Insulin (UI/mL) | 6.4 ± 1.7 | 8.45 ± 4.2 | 23.1 ± 6.2 | <0.0001 | <0.0001 |
| Alkaline phosphatase (UI/L) | 93 ± 45.2 | 112.9 ± 40.4 | 125.8 ± 47 | 0.3044 | 0.0923 |
| Total bilirubin (mg/dL) | 0.6 ± 0.2 | 0.7 ± 0.2 | 0.7 ± 0.3 | 0.1883 | 0.9803 |
| Direct bilirubin (mg/dL) | 0.2 ± 0.01 | 0.2 ± 0.04 | 0.2 ± 0.1 | 0.0524 | 0.5823 |
| HOMA-IR | 1.08 ± 0.22 | 1.08 ± 1.1 | 5.6 ± 2.2 | <0.0001 | <0.0001 |
| SBP (mmHg) | 133 ± 9.8 | 135 ± 8.9 | 140 ± 11.7 | 0.2268 | 0.0684 |
| DBP (mmHg) | 70.4 ± 2.9 | 73.4 ± 5.2 | 82.2 ± 8.8 | 0.0072 | < 0.0001 |
| Leucocyte (103/μL) | 4.66 ± 0.9 | 5.12 ± 0.8 | 6.6 ± 2.0 | 0.0359 | 0.0586 |
| Neutrophil (103/μL) | 1.86 ± 0.13 | 1.9 ± 0.4 | 4.1 ± 1.3 | 0.0002 | 0.0003 |
| Lymphocyte (103/μL) | 1.65 ± 0.31 | 1.6 ± 0.4 | 1.9 ± 0.6 | 0.6981 | 0.3611 |
| NLR | 1.1 ± 0.27 | 1.3 ± 0.5 | 2.4 ± 0.8 | 0.0021 | 0.0093 |
BMI: body mass index; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: Gamma glutamil transferase; HOMA-IR: homeostasis model assessment of insulin resistance; LDL: Low Density Lipoprotein; HDL: High Density Lipoprotein; SBP: systolic blood pressure; DBP: systolic blood pressure; NLR: Neutrophil-to-lymphocyte ratio. Normally distributed date described as mean, standard deviations (SDs), P value, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001, and unpaired Mann-Whitney U test.