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. 2020 Jun 14;9(6):523. doi: 10.3390/antiox9060523

Figure 5.

Figure 5

ERK1/2 and p38 pathways are involved in NEFA induced ROS mediated apoptosis of GCs. (A–C) After treatment with different concentrations of NEFA, p-ERK1/2, ERK1/2, p-p38, and p38 levels were assayed by western blotting. (D–F) After pre-treatment with NAC, protein expression of p-ERK1/2, ERK1/2, p-p38, and p38 were evaluated by western blotting. These results indicated that the ROS induced by NEFA activated the ERK1/2 and p38 pathways. Data are presented as mean ± SEM, * p < 0.05, and ** p < 0.01.