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. 2020 Jun 13;9(6):521. doi: 10.3390/antiox9060521

Figure 2.

Figure 2

The organ protective effect of SFN after exercise. Acute exhaustive exercise increases the production of reactive oxygen species (ROS), cytokines, and chemokines in liver and muscles. SFN treatment activates Nrf2, which translocates into the nucleus to induce production of cellular defense enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), heme oxygenase (HO) 1, NADPH quinone oxidoreductase (NQO) 1, etc. Therefore, SFN reduces ROS, cytokines, and chemokines expression.