Figure 1.

Cathelicidin-related antimicrobial peptides (CRAMP) inhibits platelet-derived growth factor-BB (PDGF-BB)-induced vascular smooth muscle cells (VSMC) Phenotypic transformation. (A) Measurement of changes in cell viability of VSMC after 48 h incubation with a range of concentrations (0, 1, 10, 100 and 1000 ng/mL) of CRAMP. (B) VSMC were pretreated with CRAMP (100 ng/mL) for 2 h and then stimulated with PDGF-BB (20 ng/mL) for 24 h followed by immunoblotting with α-SMA and SM22α antibodies. Data of 3 independent experiments is presented as mean ± SEM. ** p < 0.01; *** p < 0.001 compared with control.