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Hypoxia response element (HRE)-based genetically encoded oxygen reporters. (A) The general behavior of HRE-based oxygen reporters in normoxia, (pseudo)hypoxia and reoxygenation. (B) The dependence of HRE-based oxygen reporters’ behavior in normoxia and hypoxia on the number of HRE repeats. (C) The dependence of HRE-based oxygen reporters’ behavior in normoxia and hypoxia on the strength of the promoter.
