| hERG I/II inhibition |
The hERG (human ether-a-go-go-related
gene) encodes a potassium
ion (K+) channel and is associated with increased duration
of ventricular repolarization and prolongation of the QT interval,
which could cause arrhythmia and more severe heart failure.39 Structurally and functionally unrelated drugs
have been shown to block hERG channels, and some of these have been
withdrawn from the market40
|
If a compound is likely to be an hERG I/II inhibitor |
| Ames toxicity |
It is used to assess the potential
carcinogenic effect of chemicals
using Salmonella typhimurium. When
these mutant bacterial cells are treated with mutagenic chemicals,
it causes a reversal of mutation in bacterial cells, which enables
bacteria to grow on a media lacking in histidine. More potency of
a chemical leads to more cells forming colonies on Agar media41
|
If a compound would present a
positive result in the Ames toxicity
assay |
| hepatotoxicity |
The liver
plays a critical role in energy exchange and the
biotransformation of xenobiotics. Liver suffering from damage always
disrupt the normal metabolism and even lead to their failure42
|
The server classifies compounds
as hepatotoxic if they have
at least one pathologic or physiologic effect associated with the
disruption of the normal activity of the liver |
