Table 2.

Most frequent outcomes identified in the context of Lyme disease

Outcomes	No. of studies	Brief description
Rheumatologic	7 [21–23, 25, 26, 28, 29]	Including Lyme arthritis, myalgia, or other musculoskeletal manifestations
Neurological	7 [21–23, 25, 26, 28, 29]	Including encephalopathy, peripheral neuropathy, neuroborrelisosis, bell palsy and meningitis
Cardiological	6 [22, 23, 25, 26, 28, 29]	Including Lyme carditis or other defined cardiac sequelae
Dermatological	5 [22, 25, 26, 28, 29]	Including erythema migrans, acrodermatitis and chronica atrophicans
System challenges	5 [6, 20, 27, 30, 36]	Frustration with diagnostic delay, access issues, multiple providers, out-of-network providers and other negative system experiences
Adverse events	4 [19, 20, 25, 35]	Including major and minor events related to antibiotic treatment or vaccination strategies
Quality of life	4 [16, 17, 27, 30]	Including quality-adjusted life-year measures or other specific health related quality of life estimates
Other Lyme sequelae	3 [25, 26, 29]	Including lymphocytoma, ocular manifestations, headache, acute back pain and neck pain
Psychological	2 [6, 30]	Including stress, anxiety, or depression