Fig. 6.

Histologic location of CMBs and analysis of regional blood supply. a Prussian blue histology of CMBs in an old mouse with the Th location of CMBs shown. The blood supply in microCT (blue) to the Th shown with MRI (grey) includes b the rostral Th, with supply from the internal carotid (IC) with the dorsal and ventral thalamic arteries. The MRI slice location is similar to the location of common Th CMBs, with the Th, St, and Hi labeled from MRI. c The blood supply caudal to the Th is shown with the posterior cerebral artery (PCA), connecting via the thalamoperforating arteries. The large central vessels visible superior to the Th in b, c are longitudinal hippocampal veins. Images in b, c were reproduced from data acquired by Dorr et al. [39]) using 7.0-T MRI with 32 μm isotropic voxels and microCT with 20 μm isotropic resolution in male CBA mice ex vivo with a scale bar size of 5 mm and the slice location shown as yellow bar on inset horizontal slice