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. 2020 Jul 9;10:21. doi: 10.1186/s13395-020-00237-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Nuclear reporter mice show high SC contribution during exercise. aPax7^CreERT2 mice were crossed with Rosa^{CAG-LSL-ntdTomato} mice to genetically trace SC-derived nuclei. Upon tamoxifen treatment, SCs and SC-derived myonuclei will express nTomato (nTom). b Quantification of Hoechst⁺ and c nTom⁺ nuclei per 100 μm fiber length (11–16 single myofibers per mouse, n = 4 mice per group). d Represented pictures of single myofibers isolated from soleus. Statistics, one-way ANOVA test with Tukey correction for multiple comparisons (*p < 0.05; **p < 0.01; ***p < 0.001). Violin plot is shown (b, c). Each dot represents a single mouse. Scale bar, 25 μm