Fig. 7.

circCELSR1/miR-598/BRD4 axis regulated ovarian cancer progression in vivo. a Pictures showed the metastatic tumors in nude mice. b Quantification of average number of tumor nodules and (c) tumor weight were shown. d The gene expression of circCELSR1, miR-598 and BRD4 in xenografted tumors was measured by qRT-PCR. e Protein level of E-cadherin, Vimentin, N-cadherin, BRD4, c-Myc, CyclinD1, CDK4, MMP-2 and MMP-9 in xenografted tumors were measured by Western blotting, and (f) quantification of protein level was shown. g The protein level of BRD4, Ki-67 and Bax in tumor sections was measured by immunohistochemistry. All the results were shown as mean ± SD (n = 3). * p < 0.05 and ** p < 0.01