Table 1.
GO term enrichment analysis of DEGs
| Term | P value | Genes |
|---|---|---|
| Biological process | ||
| GO:0030198~extracellular matrix organization | 2.87E−06 | CRISPLD2, FBN1, NID1, COL1A1, SPARC, COL5A1, SPP1 |
| GO:0032355~response to estradiol | 3.72E−05 | ALDH1A2, SOCS2, PTCH1, COL1A1, PTEN |
| GO:0003007~heart morphogenesis | 3.95E−05 | FLRT2, ALDH1A2, PTCH1, COL5A1 |
| GO:0030199~collagen fibril organization | 7.20E−05 | TNXB, TNXA, COL1A1, COL5A1 |
| GO:0045893~positive regulation of transcription, DNA-templated | 7.81E−05 | FOXL2, OSR2, GDF7, IGF1, PTCH1, COL1A1, TBL1X, WT1 |
| GO:0007507~heart development | 5.49E−04 | EDNRA, FBN1, SPARC, PTEN, WT1 |
| GO:0000122~negative regulation of transcription from RNA polymerase II promoter | 6.09E−04 | FOXL2, OSR2, PTCH1, FOSB, ZEB1, TBL1X, WT1, PEG3 |
| GO:0045944~positive regulation of transcription from RNA polymerase II promoter | 7.55E−04 | FOXL2, OSR2, NDN, IGF1, FOSB, ZEB1, TBL1X, WT1, PEG3 |
| GO:0008285~negative regulation of cell proliferation | 1.29E−03 | ALDH1A2, NDN, SFRP4, ZEB1, PTEN, WT1 |
| GO:0007155~cell adhesion | 2.46E−03 | ISLR, TNXB, COL1A1, CXCL12, COL5A1, SPP1 |
| GO:0001568~blood vessel development | 2.83E−03 | ALDH1A2, COL1A1, COL5A1 |
| GO:0001658~branching involved in ureteric bud morphogenesis | 3.45E−03 | PTCH1, DCHS1, WT1 |
| GO:0043434~response to peptide hormone | 3.78E−03 | COL1A1, SPARC, CXCL12 |
| GO:0051591~response to cAMP | 4.12E−03 | COL1A1, FOSB, SPARC |
| GO:0009612~response to mechanical stimulus | 6.70E−03 | PTCH1, FOSB, CXCL12 |
| GO:0030324~lung development | 1.09E−02 | ALDH1A2, CRISPLD2, SPARC |
| GO:0022617~extracellular matrix disassembly | 1.09E−02 | FBN1, NID1, SPP1 |
| GO:0032964~collagen biosynthetic process | 1.24E−02 | COL1A1, COL5A1 |
| GO:0045606~positive regulation of epidermal cell differentiation | 1.45E−02 | SFRP4, PTCH1 |
| GO:0008284~positive regulation of cell proliferation | 1.55E−02 | ALDH1A2, OSR2, CD248, IGF1, PTEN |
| GO:0071711~basement membrane organization | 1.66E−02 | FLRT2, NID1 |
| GO:0032836~glomerular basement membrane development | 1.86E−02 | NID1, WT1 |
| GO:0002576~platelet degranulation | 1.94E−02 | ISLR, IGF1, SPARC |
| GO:0048853~forebrain morphogenesis | 2.07E−02 | GDF7, PTEN |
| GO:0048048~embryonic eye morphogenesis | 2.07E−02 | FOXL2, FBN1 |
| GO:0060322~head development | 2.07E−02 | EDNRA, OSR2 |
| GO:0006366~transcription from RNA polymerase II promoter | 2.13E−02 | FOXL2, OSR2, NDN, FOSB, WT1 |
| GO:0043065~positive regulation of apoptotic process | 2.42E−02 | ALDH1A2, FOXL2, SFRP4, WT1 |
| GO:0042493~response to drug | 2.51E−02 | PTCH1, COL1A1, FOSB, PTEN |
| GO:0007417~central nervous system development | 2.58E−02 | NDN, ZEB1, PTEN |
| GO:0014032~neural crest cell development | 2.68E−02 | EDNRA, ALDH1A2 |
| GO:0001501~skeletal system development | 3.30E−02 | FBN1, IGF1, COL1A1 |
| GO:0048738~cardiac muscle tissue development | 3.49E−02 | ALDH1A2, PTEN |
| GO:0008283~cell proliferation | 4.02E−02 | EDNRA, IGF1, ZEB1, PTEN |
| GO:0017015~regulation of transforming growth factor beta receptor signaling pathway | 4.09E−02 | LTBP4, ZEB1 |
| GO:0007411~axon guidance | 4.32E−02 | FLRT2, GDF7, CXCL12 |
| GO:0016477~cell migration | 4.98E−02 | CD248, PTEN, COL5A1 |
| Cellular component | ||
| GO:0005578~proteinaceous extracellular matrix | 3.29E−08 | FLRT2, TNXB, TNXA, CRISPLD2, CD248, LTBP4, FBN1, SPARC, COL5A1 |
| GO:0005576~extracellular region | 6.52E−07 | CFB, GDF7, LTBP4, FBN1, IGF1, NID1, SPARC, PTEN, CXCL12, COL5A1, ISLR, CRISPLD2, SFRP4, COL1A1, SPP1 |
| GO:0005615~extracellular space | 4.26E−06 | FLRT2, TNXB, GDF7, CFB, LTBP4, SFRP4, FBN1, IGF1, COL1A1, SPARC, CXCL12, RAMP1, SPP1 |
| GO:0031012~extracellular matrix | 2.38E−04 | TNXB, LTBP4, FBN1, NID1, COL1A1, COL5A1 |
| GO:0005604~basement membrane | 4.64E−04 | FBN1, NID1, SPARC, COL5A1 |
| GO:0070062~extracellular exosome | 1.41E−03 | FLRT2, TNXB, TNXA, CFB, LTBP4, CD248, FBN1, NID1, CXCL12, SLC7A5, COL5A1, ISLR, CRISPLD2, SPP1 |
| GO:0031093~platelet alpha granule lumen | 4.99E−03 | ISLR, IGF1, SPARC |
| GO:0042995~cell projection | 9.11E−03 | NDN, PTEN, SPP1 |
| Molecular function | ||
| GO:0005178~integrin binding | 5.03E−05 | TNXB, LTBP4, FBN1, IGF1, COL5A1 |
| GO:0008201~heparin binding | 2.57E−04 | TNXB, CRISPLD2, FBN1, PTCH1, COL5A1 |
| GO:0005201~extracellular matrix structural constituent | 2.99E−04 | TNXB, FBN1, COL1A1, COL5A1 |
| GO:0050840~extracellular matrix binding | 1.17E−03 | CD248, SPARC, SPP1 |
| GO:0005509~calcium ion binding | 2.39E−03 | SLC24A3, CD248, LTBP4, FBN1, NID1, SPARC, DCHS1 |
| GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | 1.08E−02 | FOXL2, NDN, FOSB, WT1 |
| GO:0043394~proteoglycan binding | 2.13E−02 | NID1, COL5A1 |
| GO:0048407~platelet-derived growth factor binding | 2.13E−02 | COL1A1, COL5A1 |
| GO:0005159~insulin-like growth factor receptor binding | 2.89E−02 | SOCS2, IGF1 |
| GO:0008083~growth factor activity | 3.98E−02 | GDF7, IGF1, CXCL12 |