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. 2020 Jul 9;20:296. doi: 10.1186/s12935-020-01366-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — OIP5-AS1 promotes PDAC cell proliferation and migration. a The level of OIP5-AS1 was measured in PANC-1 cells transfected with sh-OIP5-AS1-1, sh-OIP5-AS1-2 or CFPAC-1 cells transfected with pcDNA3.1 empty vector or pcDNA3.1/OIP5-AS1. Results were evaluated by RT-qPCR (**P < 0.01). The transfected cells were used for subsequent experiments. b, c CCK-8 and colony formation assays detected measured the cell proliferation ability in indicated groups. (**P < 0.01). d Transwell assay detected cell migration ability in PANC-1 cells transfected with indicated plasmids (**P < 0.01). e Western blot researched the effects of OIP5-AS1 depletion or up-regulation on proteins involved in EMT process and ERK signaling pathway in cells under different conditions (**P < 0.01). *P< 0.05, and **P < 0.01 indicated data were statistically significant